Details

Autor(en) / Beteiligte

• Saurí, Josep
• Parella, Teodor
• Espinosa, Juan F

Titel

CLIP-HSQMBC: easy measurement of small proton-carbon coupling constants in organic molecules

Ist Teil von

• Organic & biomolecular chemistry, 2013-07, Vol.11 (27), p.4473-4478

Ort / Verlag

England

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A user-friendly 2D NMR approach denoted as CLIP-HSQMBC is proposed for the very easy, direct and accurate measurement of long-range proton-carbon coupling constants in organic molecules and natural products. The J value can be extracted directly from the analysis of resolved in-phase (1)H multiplets that show an additional splitting arising from the proton-carbon coupling. In cases of unresolved peaks, a simple fitting analysis using the internal satellite lines as a reference is performed. Addition of a spin-lock period results in a CLIP-HSQMBC-TOCSY experiment that is suitable for the measurement of very small coupling values or to observe correlations from overlapped resonances.