Details

Autor(en) / Beteiligte

• Inubushi, Masayuki
• Saga, Tsuneo
• Koizumi, Mitsuru
• Takagi, Ryo
• Hasegawa, Azusa
• Koto, Masashi
• Wakatuki, Masaru
• Morikawa, Takamichi
• Yoshikawa, Kyosan
• Tanimoto, Katsuyuki
• Fukumura, Toshimitsu
• Yamada, Shigeru
• Kamada, Tadashi

Titel

Predictive value of 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma

Ist Teil von

• Annals of nuclear medicine, 2013, Vol.27 (1), p.1-10

Ort / Verlag

Japan: Springer Japan

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective The purpose of this prospective study was to assess the prognostic value of 3′-deoxy-3′-[ 18 F]fluorothymidine (FLT) positron emission tomography/computed tomography (PET/CT) for the outcome of carbon ion radiotherapy (CIRT) in patients with mucosal malignant melanoma (MMM) of the head and neck. Methods Thirteen patients (69 ± 13 years) with histologically proven MMM tumor were enrolled. CIRT was performed with a total dose of 57.6–64.0 gray equivalents per 16 fractions over a period of 4 weeks. FLT-PET/CT was performed before and again 1 month after CIRT. Tumor FLT uptake was quantitatively assessed using the maximum standardized uptake value (SUV max ). FLT-PET parameters [pre-CIRT SUV max , post-CIRT SUV max , and the reduction rate (RR)] and clinical parameters [age, gender, tumor site, tumor status, gross tumor volume (GTV), and regional lymph node involvement] were evaluated in relation to survival estimates. The follow-up period was 16.1 ± 5.9 months for 9 deceased patients, and 36.7 ± 7.9 months for 4 survivors. Results Pre-CIRT SUV max of ≥4.3, age of ≥80 years old, sinonasal cavity tumor site, and GTV of ≥39 mL were found to be statistically significant prognostic factors for better overall survival. Pre-CIRT SUV max of ≥5.0, age of ≥80 years old, sinonasal cavity tumor site, and the absence of regional lymph node involvement were statistically significant prognostic factors for better metastasis-free survival. RR of ≥35 % and GTV of <73 mL were predictive of better local control. Conclusions The present study indicated for the first time that in patients with the head and neck MMM, FLT-PET/CT imaging was useful for predicting the therapeutic outcome of CIRT. Our results will contribute to the establishment of an effective staging system for MMM based on prognostic factors, depending on treatment choice.