Details

Autor(en) / Beteiligte

• Soldevila, Sonia
• Bosca, Francisco

Titel

Photoreactivity of Fluoroquinolones: Nature of Aryl Cations Generated in Water

Ist Teil von

• Organic letters, 2012-08, Vol.14 (15), p.3940-3943

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The nature of stabilized aryl cations generated from photodehalogenations of fluoroquinolones in aqueous media has been studied by comparing the photophysical and photochemical behavior of lomefloxacin (LFX) and its N(4′)-acetylated form (ALFX). Photoproduct studies, laser flash photolysis, and emission measurements have shown that this small peripheral modification produces important changes in the properties of the singlet aryl cations generated. Also, in basic medium, a new photodehalogenation pathway for 6,8-dihalogenated fluoroquinolones has been observed.