Details

Autor(en) / Beteiligte

• CHEN, B
• WANG, Y.-Y
• CAO, Q
• YANG, G
• JIANG, C.-L
• WENG, X.-Q
• ZHANG, X.-X
• XIONG, S.-M
• SHEN, Z.-X
• JIANG, H
• GU, L.-J
• CHEN, Z
• SHEN, Y
• MI, J.-Q
• CHEN, S.-J
• ZHANG, W.-N
• HE, H.-Y
• ZHU, Y.-M
• CHEN, H.-M
• GU, C.-H
• FAN, X
• CHEN, J.-M

Titel

Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries

Ist Teil von

• Leukemia, 2012-07, Vol.26 (7), p.1608-1616

Ort / Verlag

Avenel, NJ: Nature Publishing Group

Erscheinungsjahr

2012

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• It has been generally acknowledged that the diagnosis, treatment and prognosis evaluation of leukemia largely rely on an adequate identification of genetic abnormalities. A systemic analysis of genetic aberrations was performed in a cohort of 1346 patients with newly diagnosed acute lymphoblastic leukemia (ALL) in China. The pediatric patients had higher incidence of hyperdiploidy and t(12;21) (p13;q22)/ETV6-RUNX1 than adults (P<0.0001); in contrast, the occurrence of Ph and Ik6 variant of IKZF1 gene was much more frequent in adult patients (all P<0.0001). In B-ALL, the existence of Ik6 and that of BCR-ABL were statistically correlated (P<0.0001). In comparison with Western cohorts, the incidence of t(9;22) (q34;q11)/BCR-ABL (14.60%) in B-ALL and HOX11 expression in T-ALL (25.24%) seemed to be much higher in our group, while the incidence of t(12;21) (p13;q22)/ETV6-RUNX1 (15.34%) seemed to be lower in Chinese pediatric patients. The occurrence of hyperdiploidy was much lower either in pediatric (10.61% vs 20-38%) or adult patients (2.36% vs 6.77-12%) in our study than in Western reports. In addition, the frequencies of HOX11L2 in adult patients were much higher in our cohort than in Western countries (20.69% vs 4-11%). In general, it seems that Chinese ALL patients bear more adverse prognostic factors than their Western counterparts do.