Details

Autor(en) / Beteiligte

• Yuan, Huipin
• Fernandes, Hugo
• Habibovic, Pamela
• de Boer, Jan
• Barradas, Ana M. C.
• de Ruiter, Ad
• Walsh, William R.
• van Blitterswijk, Clemens A.
• de Bruijn, Joost D.
• Langer, Robert

Titel

Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (31), p.13614-13619

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2010

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and structural characteristics. Microporosity correlated to their propensity to stimulate osteogenic differentiation of stem cells in vitro and bone induction in vivo. Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts. Our results provide proof of concept for the clinical application of "smart" biomaterials.