Details

Autor(en) / Beteiligte

• Chang, Tien‐Jen
• Kjeldsen, Rolf Bech
• Christfort, Juliane Fjelrad
• Vila, Eduard Marzo
• Alstrøm, Tommy Sonne
• Zór, Kinga
• Hwu, En‐Te
• Nielsen, Line Hagner
• Boisen, Anja

Titel

3D‐Printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery

Ist Teil von

• Advanced healthcare materials, 2023-02, Vol.12 (4), p.e2201897-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• During the past decades, microdevices have been evaluated as a means to overcome challenges within oral drug delivery, thus improving bioavailability. Fabrication of microdevices is often limited to planar or simple 3D designs. Therefore, this work explores how microscale stereolithography 3D printing can be used to fabricate radiopaque microcontainers with enhanced mucoadhesive geometries, which can enhance bioavailability by increasing gastrointestinal retention. Ex vivo force measurements suggest increased mucoadhesion of microcontainers with adhering features, such as pillars and arrows, compared to a neutral design. In vivo studies, utilizing planar X‐ray imaging, show the time‐dependent gastrointestinal location of microcontainers, whereas computed tomography scanning and cryogenic scanning electron microscopy reveal information about their spatial dynamics and mucosal interactions, respectively. For the first time, the effect of 3D microdevice modifications on gastrointestinal retention is traced in vivo, and the applied methods provide a much‐needed approach for investigating the impact of device design on gastrointestinal retention. For the first time, this study demonstrates how an innovative high definition digital versatile disc based microscale 3D printing setup can be used to fabricate versatile microdevices, with adhering geometric structures and incorporated contrast agent, for oral drug delivery. Generally, the presented fabrication process improves mucoadhesion and traceability of microdevices used for oral drug delivery.