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Valproic Acid in Women and Girls of Childbearing Age
Ist Teil von
Current psychiatry reports, 2017-09, Vol.19 (9), p.58, Article 58
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2017
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Purpose of Review
The aim of this paper is to evaluate recent literature on valproic acid (VPA) in women and girls of childbearing age and to emphasize new findings.
Recent Findings
Recent research confirms VPAs teratogenicity and risk of hormone disruption. VPA exposure in utero increases the risk for a variety of major congenital malformations (MCMs), reduced IQ and behavioral problems. In girls and women, VPA increases the risk of hormone abnormalities, obesity, and polycystic ovarian syndrome (PCOS). Despite guidelines recommending caution, VPA use continues to be prescribed to reproductive-aged women and girls.
Summary
Despite significant and well-documented risk, adherence to guidelines in VPA use in reproductive-aged girls and women remains low.