Details

Autor(en) / Beteiligte

• Jiang, Yuyan
• Upputuri, Paul Kumar
• Xie, Chen
• Zeng, Ziling
• Sharma, Arunima
• Zhen, Xu
• Li, Jingchao
• Huang, Jiaguo
• Pramanik, Manojit
• Pu, Kanyi

Titel

Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging

Ist Teil von

• Advanced materials (Weinheim), 2019-03, Vol.31 (11), p.e1808166-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Photoacoustic (PA) imaging in the second near‐infrared (NIR‐II) window (1000–1700 nm) holds great promise for deep‐tissue diagnosis due to the reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive imaging technique is greatly constrained by the lack of biodegradable NIR‐II absorbing agents. Herein, the first series of metabolizable NIR‐II PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist of π‐conjugated yet oxidizable optical polymer as PA generator and hydrolyzable amphiphilic polymer as particle matrix to provide water solubility. The obtained SPNs are readily degraded by myeloperoxidase and lipase abundant in phagocytes, transforming from nonfluorescent nanoparticles (30 nm) into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these nanoagents can be effectively cleared out via both hepatobiliary and renal excretions after systematic administration, leaving no toxicity to living mice. Particularly these nanoagents possess high photothermal conversion efficiencies and emit bright PA signals at 1064 nm, enabling sensitive NIR‐II PA imaging of both subcutaneous tumor and deep brain vasculature through intact skull in living animals at a low systematic dosage. This study thus provides a generalized molecular design toward organic metabolizable semiconducting materials for biophotonic applications in NIR‐II window. The first series of metabolizable photoacoustic contrast agents in the second near‐infrared window are developed based on semiconducting polymer nanoparticles. Such nanoagents can be degraded by phagocytes into ultrasmall fluorescent metabolites, followed by efficient clearance from living bodies via both renal and hepatobiliary excretions. This study thus highlights a generalized molecular design to advance organic optical imaging agents toward clinical translations.