Details

Autor(en) / Beteiligte

• Touat, M
• Olaussen, K
• Sourisseau, T
• Friboulet, L
• Dorvault, N
• Enot, D
• Bigot, L
• Pontoizeau, C
• Mardakheh, F
• Thompson, A
• Bouillaud, F
• Ricchetti, M
• Ottolenghi, C
• Pierron, G
• Sarasin, A
• Lombès, A
• Ashworth, A
• Lord, C
• Soria, J.C
• Postel-Vinay, S

Titel

NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear–mitochondrial crosstalk in ERCC1-deficient populations

Ist Teil von

• European journal of cancer (1990), 2016-12, Vol.69, p.S56-S56

Ort / Verlag

Oxford: Elsevier Science Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An abstract of a study by Touat et al identifying novel synthetic lethal therapeutic approach exploiting nuclear-mitochondrial crosstalk in ERCC1-deficient populations is presented. They found marked metabolic rewiring of ERCC1-deficient populations, including decreased NAMPT levels, decreased NAD+ levels and abnormalities in the tricarboxylic acid cycle.