Details

Autor(en) / Beteiligte

• Wu, Ming‐Xue
• Gao, Jia
• Wang, Fang
• Yang, Jie
• Song, Nan
• Jin, Xiaoyu
• Mi, Peng
• Tian, Jian
• Luo, Jiayan
• Liang, Feng
• Yang, Ying‐Wei

Titel

Multistimuli Responsive Core–Shell Nanoplatform Constructed from Fe3O4@MOF Equipped with Pillar[6]arene Nanovalves

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2018-04, Vol.14 (17), p.n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• An intelligent theranostic nanoplatform based on nanovalve operated metal–organic framework (MOF) core–shell hybrids, incorporating tumorous microenvironment‐triggered drug release, magnetic resonance imaging (MRI) guidance, sustained release, and effective chemotherapy in one pot is reported. The core–shell hybrids are constructed by an in situ growth method, in which Fe3O4 particles with superior abilities of MRI and magnetic separation form the core and UiO‐66 MOF with high loading capacity compose the shell, and then are surface‐installed with pillararene‐based pseudorotaxanes as tightness‐adjustable nanovalves. This strategy endows the system with the ability of targeted, multistimuli responsive drug release in response to pH changes, temperature variations, and competitive agents. Water‐soluble carboxylatopillar[6]arene system achieved sustained drug release over 7 days due to stronger host–guest binding, suggesting that the nanovalve tightness further reinforces the desirable release of anticancer agent over a prolonged time at the lesion site. A theranostic nanoplatform based on a water‐soluble pillararene gated magnetic core–shell metal–organic framework (MOF) is fabricated, incorporating high drug loading capacity, multistimuli responsive drug release, sustained drug release, magnetic resonance imaging synergistic diagnosis, and effective chemotherapy in one pot. Such a facile strategy provides a promising perspective for the construction of a multifunctional MOF‐based theranostic nanoplatform.