Details

Autor(en) / Beteiligte

• Zhou, Shun
• Bai, Zhou‐Lan
• Xia, Di
• Zhao, Zhi‐Jun
• Zhao, Ren
• Wang, Yan‐Yang
• Zhe, Hong

Titel

FTO regulates the chemo‐radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β‐catenin through mRNA demethylation

Ist Teil von

• Molecular carcinogenesis, 2018-05, Vol.57 (5), p.590-597

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The role of N6‐methyladenosine (m6A) demethylase fat mass and obesity‐associated protein (FTO) in the regulation of chemo‐radiotherapy resistance remains largely unknown. Here, we show that the mRNA level of FTO is elevated in cervical squamous cell carcinoma (CSCC) tissues when compared with respective adjacent normal tissues. FTO enhances the chemo‐radiotherapy resistance both in vitro and in vivo through regulating expression of β‐catenin by reducing m6A levels in its mRNA transcripts and in turn increases excision repair cross‐complementation group 1 (ERCC1) activity. Clinically, the prognostic value of FTO for overall survival is found to be dependent on β‐catenin expression in human CSCC samples. Taken together, these findings uncover a critical function for FTO and its substrate m6A in the regulation of chemo‐radiotherapy resistance, which may bear potential clinical implications for CSCC treatment.