Details

Autor(en) / Beteiligte

• Weibel, Douglas B
• Garstecki, Piotr
• Ryan, Declan
• DiLuzio, Willow R
• Mayer, Michael
• Seto, Jennifer E
• Whitesides, George M

Titel

Microoxen: Microorganisms to Move Microscale Loads

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (34), p.11963-11967

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• It is difficult to harness the power generated by biological motors to carry out mechanical work in systems outside the cell. Efforts to capture the mechanical energy of nanomotors ex vivo require in vitro reconstitution of motor proteins and, often, protein engineering. This study presents a method for harnessing the power produced by biological motors that uses intact cells. The unicellular, biflagellated algae Chlamydomonas reinhardtii serve as "microoxen." This method uses surface chemistry to attach loads (1- to 6-μm-diameter polystyrene beads) to cells, phototaxis to steer swimming cells, and photochemistry to release loads. These motile microorganisms can transport microscale loads (3-μm-diameter beads) at velocities of ≈100-200 μ m· sec-1and over distances as large as 20 cm.