Details

Autor(en) / Beteiligte

• Saito, Kozo
• Shigetomi, Eiji
• Yasuda, Rei
• Sato, Ryuichi
• Nakano, Masakazu
• Tashiro, Kei
• Tanaka, Kenji F.
• Ikenaka, Kazuhiro
• Mikoshiba, Katsuhiko
• Mizuta, Ikuko
• Yoshida, Tomokatsu
• Nakagawa, Masanori
• Mizuno, Toshiki
• Koizumi, Schuichi

Titel

Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model

Ist Teil von

• Glia, 2018-05, Vol.66 (5), p.1053-1067

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Alexander disease (AxD) is a rare neurodegenerative disorder caused by gain of function mutations in the glial fibrillary acidic protein (GFAP) gene. Accumulation of GFAP proteins and formation of Rosenthal fibers (RFs) in astrocytes are hallmarks of AxD. However, malfunction of astrocytes in the AxD brain is poorly understood. Here, we show aberrant Ca2+ responses in astrocytes as playing a causative role in AxD. Transcriptome analysis of astrocytes from a model of AxD showed age‐dependent upregulation of GFAP, several markers for neurotoxic reactive astrocytes, and downregulation of Ca2+ homeostasis molecules. In situ AxD model astrocytes produced aberrant extra‐large Ca2+ signals “AxCa signals”, which increased with age, correlated with GFAP upregulation, and were dependent on stored Ca2+. Inhibition of AxCa signals by deletion of inositol 1,4,5‐trisphosphate type 2 receptors (IP3R2) ameliorated AxD pathogenesis. Taken together, AxCa signals in the model astrocytes would contribute to AxD pathogenesis. Main Points Alexander disease (AxD) is a rare neurodegenerative disorder triggered by mutation of GFAP. Astrocytes in an AxD model mouse showed aberrant extra‐large Ca2+ (AxCa) signals that were found to contribute to progression of the pathogenesis of AxD.