Details

Autor(en) / Beteiligte

• Horton, F.
• Wright, J.
• Smith, L.
• Hinton, P. J.
• Robertson, M. D.

Titel

Increased intestinal permeability to oral chromium (51Cr) -EDTA in human Type 2 diabetes

Ist Teil von

• Diabetic medicine, 2014-05, Vol.31 (5), p.559-563

Ort / Verlag

Oxford: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective In animal models of obesity and Type 2 diabetes, permeability of the intestine is increased because of impairment of tight junction proteins, allowing translocation of bacterial endotoxin and resulting in low‐grade systemic inflammation. This has yet to be demonstrated in humans. The objective of this study was the demonstration of increased intestinal permeability in human Type 2 diabetes. Methods We examined intestinal permeability using chromium (51Cr)‐EDTA urinary recovery in twenty well‐controlled men with Type 2 diabetes compared with control subjects matched for age, gender and BMI. Results Intestinal permeability was significantly increased (P = 0.002) in the diabetic group and was correlated to increased levels of systemic inflammatory markers high‐sensitivity C‐reactive protein (r = 0.694, P = 0.001), interleukin 6 (r = 0.548, P = 0.012) and tumour necrosis factor alpha (r = 0.564, P = 0.010). Conclusion This is the first demonstration that increased intestinal permeability may be a feature of human Type 2 diabetes. What's new? There is increasing evidence linking an inflammatory cascade originating in the gut with systemic inflammation and the development of metabolic disease. An early and key feature of this cascade is an increase in intestinal permeability, although this has yet to be demonstrated in human diabetes. In this proof of concept study, we demonstrate for the first time an increase in intestinal permeability in people with Type 2 diabetes.