Details

Autor(en) / Beteiligte

• Bani Ismail, Zuhair
• Abu Abeeleh, Mahmoud
• Alzaben, Khaled R
• Abu-Halaweh, Sami A
• Aloweidi, Abdel Karim S
• Al-Ammouri, Iyad A
• Al-Essa, Mohamed K
• Jabaiti, Samir K
• Alsmady, Moaath M
• Al-Majali, Ahmad

Titel

Effects of experimental acute myocardial infarction on blood cell counts and plasma biochemical values in a nude rat model (Crl:NIH-Fox1RNU)

Ist Teil von

• Comparative clinical pathology, 2009, Vol.18 (4), p.433-437

Ort / Verlag

London: London : Springer-Verlag

Erscheinungsjahr

2009

Link zum Volltext

Quelle

2022 ECC(Springer)

Beschreibungen/Notizen

• To determine the clinical pathology parameters in nude rats (Crl:NIH-Fox1RNU) following experimental induction of acute myocardial infarction (AMI), 50 male adult nude rats weighing 250-350 g were used. Complete blood count, total and differential leukocyte counts, plasma total protein, albumin, glucose, urea, creatinine, total bilirubin, aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyl transpeptidase were determined before (time zero, T0), 1, and 5 days following experimental induction of AMI. Lactate dehydrogenase, creatinine kinase (CK), and creatinine kinase MB fraction (CK-MB) were determined at T0, 6, and 24 h following AMI. There were no significant changes in the hematological parameters at any sampling point. Among all plasma biochemical parameters studied, only CK and CK-MB were significantly elevated 6 h following induction of AMI. These data will aid scientists and researchers in the interpretation and better application of their results when using nude rats for AMI studies.