Details

Autor(en) / Beteiligte

• Guo, Shuang
• Luke, Brian T
• Henry, Amy R
• Darko, Samuel
• Brandt, Leah D
• Su, Ling
• Sun, David
• Wells, Daria
• Joseph, Kevin W
• Demirov, Dimiter
• Halvas, Elias K
• Douek, Daniel C
• Wu, Xiaolin
• Mellors, John W
• Hughes, Stephen H
• O’Doherty, Una

Titel

HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy

Ist Teil von

• PLoS pathogens, 2022-08, Vol.18 (8), p.e1010726-e1010726

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for understanding the stability of the reservoir; however, the stabilities of clones of infected T cells in persons on long-term ART are not well defined. We determined the relative stabilities of clones of infected and uninfected CD4+ T cells over time intervals of one to four years in three individuals who had been on ART for 9–19 years. The largest clones of uninfected T cells were larger than the largest clones of infected T cells. Clones of infected CD4+ T cells were more stable than clones of uninfected CD4+ T cells of a similar size. Individual clones of CD4+ T cells carrying intact, infectious proviruses can expand, contract, or remain stable over time.