Details

Autor(en) / Beteiligte

• Iaccarino, Guido
• Grassi, Guido
• Borghi, Claudio
• Carugo, Stefano
• Fallo, Francesco
• Ferri, Claudio
• Giannattasio, Cristina
• Grassi, Davide
• Letizia, Claudio
• Mancusi, Costantino
• Minuz, Pietro
• Perlini, Stefano
• Pucci, Giacomo
• Rizzoni, Damiano
• Salvetti, Massimo
• Sarzani, Riccardo
• Sechi, Leonardo
• Veglio, Franco
• Volpe, Massimo
• Muiesan, Maria Lorenza
• Shimosawa, Tatsuo

Titel

Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension

Ist Teil von

• PloS one, 2020-10, Vol.15 (10), p.e0237297

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2020

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• The global rate of intensive care unit (ICU) admission during the COVID-19 pandemic varies within countries and is among the main challenges for health care systems worldwide. Conflicting results have been reported about the response to coronavirus infection and COVID-19 outcomes in men and women. Understanding predictors of intensive care unit admission might be of help for future planning and management of the disease. We designed a cross-sectional observational multicenter nationwide survey in Italy to understand gender-related clinical predictors of ICU admission in patients with COVID-19. We analyzed information from 2378 charts of Italian patients certified for COVID-19 admitted in 26 hospitals. Three hundred ninety-five patients (16.6%) required ICU admission due to COVID19 infection, more frequently men (74%), with a higher prevalence of comorbidities (1,78±0,06 vs 1,54±0,03 p<0.05). In multivariable regression model main predictors of admission to ICU are male gender (OR 1,74 95% CI 1,36-2,22 p<0.0001) and presence of obesity (OR 2,88 95% CI 2,03-4,07 p<0.0001), chronic kidney disease (OR: 1,588; 95%, 1,036-2,434 p<0,05) and hypertension (OR: 1,314; 95% 1,039-1,662; p<0,05). In gender specific analysis, obesity, chronic kidney disease and hypertension are associated with higher rate of admission to ICU among men, whereas in women, obesity (OR: 2,564; 95% CI 1,336-4.920 p<0.0001) and heart failure (OR: 1,775 95% CI: 1,030-3,057) are associated with higher rate of ICU admission. Our study demonstrates that gender is the primary determinant of the disease's severity among COVID-19. Obesity is the condition more often observed among those admitted to ICU within both genders. Clinicaltrials.gov: NCT04331574.