PloS one, 2019-05, Vol.14 (5), p.e0216950-e0216950
2019
Details
- Autor(en) / Beteiligte
- Titel
- Combined effects of the rs9810888 polymorphism in calcium voltage-gated channel subunit alpha1 D (CACNA1D) and lifestyle behaviors on blood pressure level among Chinese children
- Ist Teil von
- PloS one, 2019-05, Vol.14 (5), p.e0216950-e0216950
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A recent GWAS Study found a new locus (rs9810888 in CACNA1D) was associated with blood pressure (BP) in Chinese adults. But whether the association exists in children is unknown. Whether lifestyle behaviors could interact with rs9810888 on BP is not clear. This study aimed to identify the association between rs9810888 and BP in children, and also explore the gene-lifestyle interaction. A case-control study was conducted among 2030 Chinese children aged 7 to 18 years. Genotyping was conducted by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Lifestyle behaviors were investigated with questionnaire. With adjustment for age, age square, sex, study group and body mass index (BMI), rs9810888 was significantly associated with diastolic BP (DBP) (b = 1.69, p = 0.021) and mean arterial BP (MAP) (b = 1.56, p = 0.010). Stratified analysis showed that the rs9810888 GG genotype carriers had higher DBP than GT/TT carriers (b = 3.78, p = 0.023) in the subgroup having protein intake (meat/fish/soybeans/egg) <twice/day, but not in the subgroup ≥twice/day. In addition, in the subgroup with screen time≥2h/day, the rs9810888 GG genotype carriers had higher DBP than GT/TT carriers (b = 5.49, p = 0.012), but not in the subgroup with screen time<2h/day. For MAP, in the subgroup having either fruits or vegetables < twice/day, the rs9810888 GG genotype carriers had higher MAP than GT/TT carriers (b = 2.64, p = 0.037), but not in the subgroup with both fruits and vegetables intake ≥twice/day. Additionally, in the subgroup with screen time≥2h/day, the rs9810888 GG genotype carriers had higher MAP than GT/TT carriers (b = 4.80, p = 0.017), but not in those with screen time<2h/day. The CACNA1D rs9810888 polymorphism was significantly associated with DBP and MAP. In addition, unhealthy lifestyle behaviors and rs9810888 GG genotype had combined effects on BP level among Chinese children.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0216950Titel-ID: cdi_plos_journals_2232662709
- Format
- –
- Schlagworte
- Adolescent, Alleles, Asian Continental Ancestry Group, Behavior, Biology and Life Sciences, Blood pressure, Blood Pressure - physiology, Body mass, Body Mass Index, Body size, Calcium, Calcium channels, Calcium channels (voltage-gated), Calcium Channels, L-Type - genetics, Cardiovascular disease, Carriers, Case-Control Studies, Child, Children, Children & youth, Childrens health, Control methods, Diet, Western - adverse effects, Dietary Proteins - administration & dosage, Epidemiology, Exercise, Exercise - physiology, Female, Fruit - chemistry, Fruits, Fruits (Food), Gene Expression, Gene Frequency, Gene polymorphism, Gene-Environment Interaction, Genes, Genetic aspects, Genetic polymorphisms, Genetic research, Genomes, Genotype, Genotype & phenotype, Genotyping, Health aspects, Humans, Hypertension, Hypertension - diagnosis, Hypertension - ethnology, Hypertension - genetics, Hypertension - physiopathology, Influence, Ionization, Ions, Life style, Lifestyles, Male, Mass spectrometry, Mass spectroscopy, Maternal & child health, Meat, Medicine and Health Sciences, Metabolism, People and Places, Physical Sciences, Polymorphism, Polymorphism, Single Nucleotide, Public health, Scientific imaging, Sedentary Behavior, Social Sciences, Soybeans, Spectroscopy, Studies, Subgroups, Surveys and Questionnaires, Teenagers, Vegetables, Vegetables - chemistry, Video Games