PloS one, 2016-01, Vol.11 (1), p.e0146048-e0146048
2016
Details
- Autor(en) / Beteiligte
- Titel
- Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population
- Ist Teil von
- PloS one, 2016-01, Vol.11 (1), p.e0146048-e0146048
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Anti-ganglionic nicotinic acetylcholine receptor (gAChR) antibodies are observed in autoimmune diseases, as well as in patients with autoimmune autonomic ganglionopathy. However, the genetic background of anti-gAChR antibodies is unclear. Here, we investigated HLA alleles in autoimmune hepatitis (AIH) patients with or without anti-gAChR antibodies. Genomic DNA from 260 patients with type-1 autoimmune hepatitis (AIH) were genotyped for HLA-A, B, DRB1, and DQB1 loci. Anti-gAChR antibodies in the sera form AIH patients were measured using the luciferase immunoprecipitation system, and examined allelic association in patients with or without anti-gAChR antibodies. We detected anti-α3 or -β4 gAChR antibodies in 11.5% (30/260) of patients with AIH. Among AIH patients there was no significant association between HLA-A, B DQB1 alleles and the positivity for anti-gAChR antibodies. Whereas the HLA-DRB1*0403 allele showed a significantly increased frequency in AIH patients with anti-gAChR antibodies compared with those without anti-gAChR antibodies. The frequency of the HLA-DRB1*0403 allele differed among Japanese patients with AIH according to the presence or absence of anti-gAChR antibodies. Our findings suggest that particular HLA class II molecules might control the development of anti-gAChR antibodies in the autoimmune response to gAChR.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0146048Titel-ID: cdi_plos_journals_1760021846
- Format
- –
- Schlagworte
- Adolescent, Adult, Age, Age of Onset, Aged, Aged, 80 and over, Alcohol, Alleles, Antibodies, Antigens, Asian Continental Ancestry Group - genetics, Autoantibodies - immunology, Autoimmune diseases, Autoimmune Diseases - epidemiology, Biology and Life Sciences, Case-Control Studies, Comorbidity, Deoxyribonucleic acid, DNA, Drb1 protein, Female, Follow-Up Studies, Gene Frequency, Genes, MHC Class I, Genes, MHC Class II, Genetic Predisposition to Disease, Genotype, Hepatitis, Hepatitis, Autoimmune - ethnology, Hepatitis, Autoimmune - genetics, Hepatitis, Autoimmune - immunology, Hepatology, Histocompatibility antigen HLA, HLA Antigens - genetics, HLA-D Antigens - genetics, HLA-DRB1 Chains - genetics, Humans, Immunoglobulins, Immunoprecipitation, Japan, Liver diseases, Male, Medicine and Health Sciences, Middle Aged, Nerve Tissue Proteins - immunology, Patients, Physical Sciences, Population genetics, Receptors, Nicotinic - immunology, Research and Analysis Methods, Rheumatoid arthritis, University graduates, Young Adult