Details

Autor(en) / Beteiligte

• Fellay, Jacques
• Ge, Dongliang
• Shianna, Kevin V
• Colombo, Sara
• Ledergerber, Bruno
• Cirulli, Elizabeth T
• Urban, Thomas J
• Zhang, Kunlin
• Gumbs, Curtis E
• Smith, Jason P
• Castagna, Antonella
• Cozzi-Lepri, Alessandro
• De Luca, Andrea
• Easterbrook, Philippa
• Günthard, Huldrych F
• Mallal, Simon
• Mussini, Cristina
• Dalmau, Judith
• Martinez-Picado, Javier
• Miro, José M
• Obel, Niels
• Wolinsky, Steven M
• Martinson, Jeremy J
• Detels, Roger
• Margolick, Joseph B
• Jacobson, Lisa P
• Descombes, Patrick
• Antonarakis, Stylianos E
• Beckmann, Jacques S
• O'Brien, Stephen J
• Letvin, Norman L
• McMichael, Andrew J
• Haynes, Barton F
• Carrington, Mary
• Feng, Sheng
• Telenti, Amalio
• Goldstein, David B
• McCarthy, Mark I.

Titel

Common genetic variation and the control of HIV-1 in humans

Ist Teil von

• PLoS genetics, 2009-12, Vol.5 (12), p.e1000791-e1000791

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.