Details

Autor(en) / Beteiligte

• Chen, Zhaowei
• Li, Hongjun
• Bian, Yijie
• Wang, Zejun
• Chen, Guojun
• Zhang, Xudong
• Miao, Yimin
• Wen, Di
• Wang, Jinqiang
• Wan, Gang
• Zeng, Yi
• Abdou, Peter
• Fang, Jun
• Li, Song
• Sun, Cheng-Jun
• Gu, Zhen

Titel

Bioorthogonal catalytic patch

Ist Teil von

• Nature nanotechnology, 2021-08, Vol.16 (8), p.933-941

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Springer Nature - Connect here FIRST to enable access

Beschreibungen/Notizen

• Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the selective labelling of biomolecules or in situ synthesis of bioactive agents via non-natural processes. However, the effective deployment of bioorthogonal catalysis in vivo remains challenging, mired by the safety concerns of metal toxicity or complicated procedures to administer catalysts. Here, we describe a bioorthogonal catalytic device comprising a microneedle array patch integrated with Pd nanoparticles deposited on TiO nanosheets. This device is robust and removable, and can mediate the local conversion of caged substrates into their active states in high-level living systems. In particular, we show that such a patch can promote the activation of a prodrug at subcutaneous tumour sites, restoring its parent drug's therapeutic anticancer properties. This in situ applied device potentiates local treatment efficacy and eliminates off-target prodrug activation and dose-dependent side effects in healthy organs or distant tissues.