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DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling
Ist Teil von
Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6356), p.1126-1130
Ort / Verlag
United States: American Association for the Advancement of Science
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Science Online_科学在线
Beschreibungen/Notizen
Shape-changing hydrogels that can bend, twist, or actuate in response to external stimuli are critical to soft robots, programmable matter, and smart medicine. Shape change in hydrogels has been induced by global cues, including temperature, light, or pH. Here we demonstrate that specific DNA molecules can induce 100-fold volumetric hydrogel expansion by successive extension of cross-links. We photopattern up to centimeter-sized gels containing multiple domains that undergo different shape changes in response to different DNA sequences. Experiments and simulations suggest a simple design rule for controlled shape change. Because DNA molecules can be coupled to molecular sensors, amplifiers, and logic circuits, this strategy introduces the possibility of building soft devices that respond to diverse biochemical inputs and autonomously implement chemical control programs.