Details

Autor(en) / Beteiligte

• Åhs, Eva
• Barroso, João
• Batista Leite, Sofia
• Berggren, Elisabet
• Campia, Ivana
• Carpi, Donatella
• Casati, Silvia
• Coecke, Sandra
• Corvi, Raffaella
• Deceuninck, Pierre
• Dura, Adelaide
• Franco, Antonio
• Gribaldo, Laura
• Holloway, Marcelle
• Langezaal, Ingrid
• Madia, Federica
• Munn, Sharon
• Paini, Alicia
• Piergiovanni, Monica
• Pistollato, Francesca
• Price, Anna
• Prieto Peraita, Pilar
• Sund, Jukka
• Wittwehr, Clemens
• Whelan, Maurice
• Worth, Andrew
• Zuang, Valérie

Titel

Non-animal methods in science and regulation: EURL ECVAM status report 2021

Ort / Verlag

Luxembourg: Publications Office

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The 2021 EURL ECVAM status report describes research, development and validation activities, as well as initiatives that promote the uptake and use of non-animal methods and approaches in science and regulation. The principle of the Three Rs, i.e. Replacement, Reduction and Refinement of animal use in basic, applied and translational research, as well as for regulatory purposes is firmly anchored in EU legislation, with full replacement of animal testing being the ultimate goal. New approach methodologies including a variety of innovative technologies, such as in vitro methods using 3D tissues and cells, organ-on-chip, computational models (including artificial intelligence) and 'omics (genomics, proteomics, metabolomics), are developed, evaluated and integrated in assessment frameworks with a view to improve the efficiency and effectiveness of hazard and risk assessment of chemicals and products in a variety of regulatory contexts. Important activities to promote the development and use of non-animal approaches are also pursued in the areas of basic and applied research, where most of the animals are used, as well as for education purposes.