Details

Autor(en) / Beteiligte

• Ma, Sai-Nan
• Mao, Zhi-Xiang
• Wu, Yang
• Liang, Ming-Xing
• Wang, Dan-Dan
• Chen, Xiu
• Chang, Ping-an
• Zhang, Wei
• Tang, Jin-Hai

Titel

The anti-cancer properties of heparin and its derivatives: a review and prospect

Ist Teil von

• Cell adhesion & migration, 2020-01, Vol.14 (1), p.118-128

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase, P-/L-selectin, angiogenesis, and interference with the CXCL12-CXCR4 axis. Here we summarize the current experimental evidence regarding the anti-cancer role of heparin and its derivatives, and conclude that there is evidence to support heparin's role in inhibiting cancer progression, making it a promising anti-cancer agent.