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Systemic arterial compliance is reduced in young patients with IDDM
Ist Teil von
American journal of physiology. Heart and circulatory physiology, 1999-06, Vol.276 (6), p.H1839-H1845
Ort / Verlag
United States
Erscheinungsjahr
1999
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
1 Cardiovascular Centre, Centre
for Heart and Chest Research, Monash University and Monash Medical
Centre; 3 Diabetes Unit, Monash
Medical Centre, Clayton 3168; and
2 Department of Electrical
Engineering, Latrobe University, Bundoora, Victoria 3083, Australia
Arterial elastic properties are altered with
increasing age and in various disease states, including
non-insulin-dependent diabetes mellitus (NIDDM). Whether young patients
with insulin-dependent diabetes mellitus (IDDM) have reduced arterial
compliance before developing endothelial dysfunction or overt micro-
and macrovascular disease is unclear. Systemic arterial compliance and
endothelium-dependent, flow-mediated vasodilation (FMD) was assessed in
25 individuals with uncomplicated IDDM (23 ± 4 yr, 14 females and 11 males) and compared with 30 age-matched controls (15 females and 15 males). Arterial compliance was determined via
simultaneous measurements of aortic blood flow and carotid arterial
pressure. The relationship between arterial compliance and endothelial
function (assessed by brachial artery FMD) was also examined. Arterial
compliance was 29% lower in IDDM subjects compared with control
subjects (0.46 ± 0.05 vs. 0.65 ± 0.07 arbitrary compliance
units, P < 0.05). Blood pressure,
lipid levels, and daily energy expenditure (a measure of physical
activity levels) were not different between groups. Compliance in the
IDDM group was not related to the integrity of endothelial vasodilator
function, disease duration, or degree of glycemic control. Arterial
compliance is reduced in young patients with IDDM before the
development of overt micro- or macrovascular disease. Early assessment
of arterial compliance may be useful in predicting the development of
diabetic vascular complications.
arterial stiffness; diabetes; insulin-dependent diabetes mellitus; endothelium