The New England journal of medicine, 2020-03, Vol.382 (13), p.1232-1243
2020
Details
- Autor(en) / Beteiligte
- Titel
- Fostemsavir in Adults with Multidrug-Resistant HIV-1 Infection
- Ist Teil von
- The New England journal of medicine, 2020-03, Vol.382 (13), p.1232-1243
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- In this international trial involving 371 patients with highly drug-resistant HIV-1 infection, fostemsavir reduced the HIV-1 RNA level by 0.79 log 10 copies per milliliter during the first 8 days of treatment. At week 48, more than half the patients treated with fostemsavir and an optimized background regimen had a virologic response.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa1902493Titel-ID: cdi_hal_primary_oai_HAL_inserm_03334407v1
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, Adult, Aged, AIDS, Anti-Retroviral Agents - therapeutic use, Antiretroviral agents, Antiretroviral drugs, Binding sites, CD4 antigen, CD4 Lymphocyte Count, Drug dosages, Drug Resistance, Multiple, Viral, Drug therapy, Drug Therapy, Combination, FDA approval, Female, Genetic aspects, Glycoprotein gp120, HIV, HIV infection, HIV Infections - drug therapy, HIV-1 - genetics, Human immunodeficiency virus, Humans, Infections, Life Sciences, Lymphocytes T, Male, Middle Aged, Multidrug resistance, Multidrug resistant organisms, Organophosphates - therapeutic use, Patient outcomes, Piperazines - therapeutic use, Prodrugs, Prodrugs - therapeutic use, Ribonucleic acid, RNA, RNA, Viral - blood, Testing, Viral Load - drug effects