Details

Autor(en) / Beteiligte

• Vautier, Mathieu
• Dupont, Axelle
• de Boysson, Hubert
• Comarmond, Chloé
• Mirault, Tristan
• Mekinian, Arsène
• Lambert, Marc
• Ferfar, Yasmina
• Aouba, Achille
• Cacoub, Patrice
• Resche-Rigon, Matthieu
• Saadoun, David

Titel

Prognosis of large vessel involvement in large vessel vasculitis

Ist Teil von

• Journal of autoimmunity, 2020-03, Vol.108, p.102419-102419, Article 102419

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• To assess prognosis factors and outcome of large vessel involvement (LVI) in large vessels vasculitis (LVV) patients. Retrospective multicenter study of characteristics and outcomes of 417 patients with LVI including 299 Takayasu arteritis (TAK) and 118 Giant cell arteritis (GCA-LVI) were analyzed. Logistic regression analysis assessed prognosis factors in LVV patients. Outcome of LVI among TAK and GCA-LVI patients (ischemic complications, aneurysms complications, relapses and revascularization) were assessed. In multivariable analysis, stroke/transient ischemic attack [HR: 3.63 (1.46–9.04), p = 0.006] was independently associated with vascular complications in LVV. The 10-years aneurysm free survival was significantly lower [67% (48–93) vs 89% (84–95), p = 0.02] in GCA-LVI compare to TAK patients. The 5-years relapse free survival was significantly lower [47% (37–60) vs 69% (63–75), p < 0.001,] in GCA-LVI compare to TAK patients. The 10-years revascularization free survival was significantly lower [55% (48–64) vs 76% (59–99), p < 0.001] in TAK compare to GCA-LVI patients. After a median follow-up of 5 years, 16 (5.4%) TAK and 7 (5.9%) GCA-LVI patients died, mainly of aneurysm (26%) and ischemic complications (26%). This large nationwide cohort of LVI provided prognosis factors of vascular complications in LVV patients. TAK and GCA-LVI have different long-term outcome in term of aneurysm development, relapse and revascularization. •Stroke increase by 4 times the odd of vascular complications and/or death in large vessel vasculitis.•GCA-LVI develop more aneurysm and have higher relapse rate than patients with TAK.•TAK patients have more large vessel stenosis and revascularization than GCA-LVI patients.