Details

Autor(en) / Beteiligte

• Benfenati, Fabio
• Cimino, Mauro
• Zoli, Michele
• Grimaldi, Roberta
• Zini, Isabella
• Agnati, Luigi F.

Titel

Decrease in mRNA levels but not in the density of D 2 dopamine receptors in rat striatum after transient forebrain ischemia

Ist Teil von

• Neuroscience letters, 1991, Vol.126 (1), p.6-8

Ort / Verlag

Elsevier Ireland Ltd

Erscheinungsjahr

1991

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• D 2 dopamine receptor mRNA was analyzed by in situ hybridization histochemistry in rat striatum 7 days after transient forebrain ischemia. A patchy disappearance of the D 2 receptor mRNA was observed in the dorsolateral striatum. In the same area, a disappearance of D 1 binding sites occurred in the absence of significant changes in D 2 receptor density. These results suggest that, although D 2 receptors seem to be apparently unaffected after forebrain ischemia, a long-lasting impairment of their neosynthesis may be present in striatal D 2 dopaminoceptive neurons.