Details

Autor(en) / Beteiligte

• Xu, Hao
• Agalioti, Theodora
• Zhao, Jun
• Steglich, Babett
• Wahib, Ramez
• Vesely, Maria Carolina Amezcua
• Bielecki, Piotr
• Bailis, Will
• Jackson, Ruaidhri
• Perez, Daniel
• Izbicki, Jakob
• Licona-Limón, Paula
• Kaartinen, Vesa
• Geginat, Jens
• Esplugues, Enric
• Tolosa, Eva
• Huber, Samuel
• Flavell, Richard A.
• Gagliani, Nicola

Titel

The induction and function of the anti-inflammatory fate of TH17 cells

Ist Teil von

• Nature communications, 2020-07, Vol.11 (1), p.3334-13, Article 3334

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Electronic Journals Library - Freely accessible e-journals

Beschreibungen/Notizen

• Abstract T H 17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of T H 17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S . aureus . Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in T H 17 cells. Our data thus indicate a key function of T H 17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of T H 17 cells with regard to environmental changes.