Details

Autor(en) / Beteiligte

• Abdolahi, Shahrokh
• Ghazvinian, Zeinab
• Muhammadnejad, Samad
• Saleh, Mahshid
• Asadzadeh Aghdaei, Hamid
• Baghaei, Kaveh

Titel

Patient-derived xenograft (PDX) models, applications and challenges in cancer research

Ist Teil von

• Journal of translational medicine, 2022-05, Vol.20 (1), p.206-206, Article 206

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.