Details

Autor(en) / Beteiligte

• Noto, Alessandra
• Suffiotti, Madeleine
• Joo, Victor
• Mancarella, Antonio
• Procopio, Francesco A.
• Cavet, Guy
• Leung, Yvonne
• Corpataux, Jean-Marc
• Cavassini, Matthias
• Riva, Agostino
• Stamatatos, Leonidas
• Gottardo, Raphael
• McDermott, Adrian B.
• Koup, Richard A.
• Fenwick, Craig
• Perreau, Matthieu
• Pantaleo, Giuseppe

Titel

The deficiency in Th2-like Tfh cells affects the maturation and quality of HIV-specific B cell response in viremic infection

Ist Teil von

• Frontiers in immunology, 2022-08, Vol.13, p.960120-960120

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B cells. We have found that the expression of CXCR3 defines distinct Tfh subsets: CXCR3 + Th1-like Tfh cells mainly producing single IFN-γ and dual IL-21/IFN-γ and CXCR3 - Th2-like Tfh cells mainly producing single IL-4 and dual IL-21/IL-4 cytokines. CXCR3 - Th2-like Tfhs are significantly reduced during ongoing HIV replication. While the percentage of Th2-like Tfh cells correlates with that of total and cycling HIV-specific B cells, the percentage of CXCR3 + Th1-like Tfhs correlates with HIV-specific B cells expressing T-bet and CXCR3. Of note, only IL-4 and IL-21 cytokines boosted efficient maturation of HIV-specific B cells while IFN-γ induced expression of T-bet and CXCR3 in B cells. Interestingly, total and HIV-specific CXCR3 + B cells showed lower rate of somatic hypermutation, as compared to CXCR3 - B cells. Therefore, the imbalance in Th2/Th1-like Tfhs affects B cell responses in viremic HIV infection.