Details

Autor(en) / Beteiligte

• Dabral, Saumya
• Turberg, Mathias
• Wanninger, Andrea
• Bolm, Carsten
• Hernández, José G

Titel

Mechanochemical Lignin-Mediated Strecker Reaction

Ist Teil von

• Molecules (Basel, Switzerland), 2017-01, Vol.22 (1), p.146-146

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2017

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A mechanochemical Strecker reaction involving a wide range of aldehydes (aromatic, heteroaromatic and aliphatic), amines, and KCN afforded a library of α-aminonitriles upon mechanical activation. This multicomponent process was efficiently activated by lignocellulosic biomass as additives. Particularly, commercially available Kraft lignin was found to be the best activator for the addition of cyanide to the in situ formed imines. A comparative study of the P-NMR (Nuclear Magnetic Resonance) along with IR (Infrared) data analysis for the Kraft lignin and methylated Kraft lignin samples ascertained the importance of the free hydroxyl groups in the activation of the mechanochemical reaction. The solvent-free mechanochemical Strecker reaction was then coupled with a lactamization process leading to the formation of the -benzylphthalimide ( ) and the isoindolinone derivative .