Details

Autor(en) / Beteiligte

• Ding, Li
• Ni, Jie
• Yang, Fan
• Huang, Lingli
• Deng, Heng
• Wu, Yang
• Ding, Xuansheng
• Tang, Jinhai

Titel

Promising therapeutic role of miR-27b in tumor

Ist Teil von

• Tumor Biology, 2017-03, Vol.39 (3), p.1010428317691657-1010428317691657

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• MicroRNAs are small nonprotein-encoding RNAs ranging from 18 to 25 nucleotides in size and regulate multiple biological pathways via directly targeting a variety of associated genes in cancers. MicroRNA-27b is a highly conserved MicroRNA throughout vertebrates and there are two homologs (hsa-miR-27a and hsa-miR-27b) in humans. MicroRNA-27b is an intragenic microRNA located on chromosome 9q22.1 within the C9orf3 gene, clustering with miR-23b and miR-24-1 in human. As a frequently dysregulated microRNA in human cancers, microRNA-27b could function as a tumor suppressor or an oncogenic microRNA. More and more studies indicate that microRNA-27b is involved in affecting various biological processes, such as angiogenesis, proliferation, metastasis, and drug resistance, and thus may act as a promising therapeutic target in human cancers. In this review, we discuss the role of microRNA-27b in detail and offer novel insights into molecular targeting therapy for cancers.