Nature communications, 2020-05, Vol.11 (1), p.2251-6, Article 2251
2020
Details
- Autor(en) / Beteiligte
- Titel
- A human monoclonal antibody blocking SARS-CoV-2 infection
- Ist Teil von
- Nature communications, 2020-05, Vol.11 (1), p.2251-6, Article 2251
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-020-16256-yTitel-ID: cdi_doaj_primary_oai_doaj_org_article_d72494b81b034a06b5cf561dbf0e29c0
- Format
- –
- Schlagworte
- Angiotensin-Converting Enzyme 2, Animals, Antibodies, Monoclonal - immunology, Antibodies, Monoclonal - pharmacology, Antibodies, Neutralizing - immunology, Antibodies, Neutralizing - pharmacology, Antibodies, Viral - immunology, Antibodies, Viral - pharmacology, Antibody Affinity - immunology, Betacoronavirus - chemistry, Betacoronavirus - drug effects, Betacoronavirus - immunology, Cell culture, Chlorocebus aethiops, Conserved Sequence, Coronaviridae, Coronavirus Infections - drug therapy, Coronavirus Infections - immunology, Coronavirus Infections - prevention & control, Coronavirus Infections - virology, Coronaviruses, COVID-19, COVID-19 vaccines, Cross Reactions - immunology, Epidemics, Epitopes, Epitopes, B-Lymphocyte - chemistry, Epitopes, B-Lymphocyte - immunology, Health services, Humans, In Vitro Techniques, Inhibitory Concentration 50, Medical treatment, Models, Molecular, Monoclonal antibodies, Neutralizing, Pandemics - prevention & control, Peptidyl-Dipeptidase A - chemistry, Peptidyl-Dipeptidase A - metabolism, Pneumonia, Viral - drug therapy, Pneumonia, Viral - immunology, Pneumonia, Viral - prevention & control, Pneumonia, Viral - virology, Protein Binding - drug effects, Protein Domains - immunology, Receptors, Virus - chemistry, Receptors, Virus - metabolism, Respiratory diseases, SARS Virus - chemistry, SARS Virus - drug effects, SARS Virus - immunology, SARS-CoV-2, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Spike Glycoprotein, Coronavirus - chemistry, Spike Glycoprotein, Coronavirus - immunology, Vaccines, Vero Cells, Viral diseases, Viruses