Details

Autor(en) / Beteiligte

• Réu, Pedro
• Khosravi, Azadeh
• Bernard, Samuel
• Mold, Jeff E.
• Salehpour, Mehran
• Alkass, Kanar
• Perl, Shira
• Tisdale, John
• Possnert, Göran
• Druid, Henrik
• Frisén, Jonas

Titel

The Lifespan and Turnover of Microglia in the Human Brain

Ist Teil von

• Cell reports (Cambridge), 2017-07, Vol.20 (4), p.779-784

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglia last for more than two decades. Furthermore, we find no evidence for the existence of a substantial population of quiescent long-lived cells, meaning that the microglia population in the human brain is sustained by continuous slow turnover throughout adult life. [Display omitted] •Human microglia renew at a median rate of 28% per year•Microglial cells are on average 4.2 years old•Most of the microglia population (>96%) is renewed throughout life Taking advantage of the decreasing level of atmospheric 14C since the Cold War, Réu et al. show that human microglia, unlike most other hematopoietic lineages, slowly turn over at a yearly median rate of 28%. The absence of a large quiescent subpopulation indicates that most microglia will renew throughout life.