Nutrients, 2021-01, Vol.13 (1), p.241
2021
Details
- Autor(en) / Beteiligte
- Titel
- Effects of High Glucose and Lipotoxicity on Diabetic Podocytes
- Ist Teil von
- Nutrients, 2021-01, Vol.13 (1), p.241
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Glomerular podocytes are highly differentiated cells that cover glomerular capillaries from the outside and have a characteristic morphology with numerous foot processes. The formation of slit membranes between the foot processes serves as a final filtration barrier for urine filtration from the blood. Podocyte damage causes disruption of the slit membrane, subsequent proteinuria and finally glomerulosclerosis, which is a common pathway in various types of chronic kidney disease (CKD). In recent years, there has been an increase in diabetes, due to rapid lifestyle changes, which is the main cause of CKD. Therefore, understanding the effect of diabetic status on podocytes is of great importance to establish a strategy for preventing CKD progression. In this review, we summarize altered glucose and lipid metabolism in diabetic podocytes and also discuss the reversibility of the changes in podocyte phenotype.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6643eISSN: 2072-6643DOI: 10.3390/nu13010241Titel-ID: cdi_doaj_primary_oai_doaj_org_article_d0ed4289173d4bc1a268eac1cb9cb57f
- Format
- –
- Schlagworte
- Apoptosis, Capillaries, Cell cycle, Cell differentiation, Chronic kidney failure, Deoxyribonucleic acid, Dextrose, Diabetes, Diabetes mellitus, Diabetic nephropathy, DNA, DNA methylation, Endoplasmic reticulum, Epigenetics, Feet, Filtration, Gene expression, Glucose, Glucose metabolism, high glucose, Hyperglycemia, Insulin, Kidney diseases, Kinases, Lipid metabolism, Lipids, lipotoxicity, Membranes, Metabolism, Phenotypes, Physical characteristics, Physiological aspects, podocyte, Proteins, Proteinuria, Review, Transcription factors, Type 2 diabetes