Details

Autor(en) / Beteiligte

• Lim, Jae Sung
• Jeon, Eun Jae
• Go, Hye Sun
• Kim, Hyung-Jin
• Kim, Kye Young
• Nguyen, Thi Quynh Trang
• Lee, Da Young
• Kim, Kyu Suk
• Pietrocola, Federico
• Hong, Seol Hee
• Lee, Shee Eun
• Kim, Kyoung-Shim
• Park, Tae-Shin
• Choi, Dong-Hee
• Jeong, Yu-Jin
• Park, Jong-Hwan
• Kim, Hyeon Sik
• Min, Jung-Joon
• Kim, Yong Sook
• Park, Joon Tae
• Cho, Jae-Ho
• Lee, Gil-Woo
• Lee, Ji Hyeon
• Choy, Hyon E
• Park, Sang Chul
• Lee, Chul-Ho
• Rhee, Joon Haeng
• Serrano, Manuel
• Cho, Kyung A

Titel

Mucosal TLR5 activation controls healthspan and longevity

Ist Teil von

• Nature communications, 2024-01, Vol.15 (1), p.46-46, Article 46

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Addressing age-related immunological defects through therapeutic interventions is essential for healthy aging, as the immune system plays a crucial role in controlling infections, malignancies, and in supporting tissue homeostasis and repair. In our study, we show that stimulating toll-like receptor 5 (TLR5) via mucosal delivery of a flagellin-containing fusion protein effectively extends the lifespan and enhances the healthspan of mice of both sexes. This enhancement in healthspan is evidenced by diminished hair loss and ocular lens opacity, increased bone mineral density, improved stem cell activity, delayed thymic involution, heightened cognitive capacity, and the prevention of pulmonary lung fibrosis. Additionally, this fusion protein boosts intestinal mucosal integrity by augmenting the surface expression of TLR5 in a certain subset of dendritic cells and increasing interleukin-22 (IL-22) secretion. In this work, we present observations that underscore the benefits of TLR5-dependent stimulation in the mucosal compartment, suggesting a viable strategy for enhancing longevity and healthspan.