Molecules (Basel, Switzerland), 2016-06, Vol.21 (6), p.776
2016
Details
- Autor(en) / Beteiligte
- Titel
- A New One-Pot Synthesis of Quinoline-2-carboxylates under Heterogeneous Conditions
- Ist Teil von
- Molecules (Basel, Switzerland), 2016-06, Vol.21 (6), p.776
- Ort / Verlag
- Switzerland: MDPI
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Quinoline-2-carboxylates are an important subclass of quinoline derivatives largely present in a variety of biologically active molecules, as well as useful ligands in metal-catalyzed reactions. Herein, we present a new one-pot protocol for synthesizing this class of derivatives starting from β-nitroacrylates and 2-aminobenzaldehydes. In order to optimize the protocol, we investigated several reaction conditions, obtaining the best results using the 2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) as solid base, in acetonitrile. Finally, we demonstrated the generality of our approach over several substrates which led to synthesize a plethora of functionalized quinolines-2-carboxylate derivatives in good overall yields.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules21060776Titel-ID: cdi_doaj_primary_oai_doaj_org_article_c30a49cede7546968bb5b2f54a0c0e31
- Format
- –
- Schlagworte
- Carboxylic Acids - chemical synthesis, Carboxylic Acids - chemistry, Catalysis, Communication, heterocycles, Heterocyclic Compounds, 1-Ring - chemistry, Ligands, Metals - chemistry, one-pot processes, Organophosphorus Compounds - chemistry, quinolines, Quinolines - chemical synthesis, Quinolines - chemistry, solid supported reagents, β-nitroacrylates