Nature communications, 2018-07, Vol.9 (1), p.2561-14, Article 2561
- Khairnar, Vishal
- Duhan, Vikas
- Patil, Ashwini M
- Zhou, Fan
- Bhat, Hilal
- Thoens, Christine
- Sharma, Piyush
- Adomati, Tom
- Friendrich, Sarah-Kim
- Bezgovsek, Judith
- Dreesen, Janine D
- Wennemuth, Gunther
- Westendorf, Astrid M
- Zelinskyy, Gennadiy
- Dittmer, Ulf
- Hardt, Cornelia
- Timm, Jörg
- Göthert, Joachim R
- Lang, Philipp A
- Singer, Bernhard B
- Lang, Karl S
2018
Details
- Autor(en) / Beteiligte
- Khairnar, Vishal
- Duhan, Vikas
- Patil, Ashwini M
- Zhou, Fan
- Bhat, Hilal
- Thoens, Christine
- Sharma, Piyush
- Adomati, Tom
- Friendrich, Sarah-Kim
- Bezgovsek, Judith
- Dreesen, Janine D
- Wennemuth, Gunther
- Westendorf, Astrid M
- Zelinskyy, Gennadiy
- Dittmer, Ulf
- Hardt, Cornelia
- Timm, Jörg
- Göthert, Joachim R
- Lang, Philipp A
- Singer, Bernhard B
- Lang, Karl S
- Titel
- CEACAM1 promotes CD8 + T cell responses and improves control of a chronic viral infection
- Ist Teil von
- Nature communications, 2018-07, Vol.9 (1), p.2561-14, Article 2561
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Dysfunction of CD8 T cells can lead to the development of chronic viral infection. Identifying mechanisms responsible for such T cell dysfunction is therefore of great importance to understand how to prevent persistent viral infection. Here we show using lymphocytic choriomeningitis virus (LCMV) infection that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is fundamental for recruiting lymphocyte-specific protein kinase (Lck) into the T cell receptor complex to form an efficient immunological synapse. CEACAM1 is essential for activation of CD8 T cells, and the absence of CEACAM1 on virus-specific CD8 T cells limits the antiviral CD8 T cell response. Treatment with anti-CEACAM1 antibody stabilizes Lck in the immunological synapse, prevents CD8 T cell exhaustion, and improves control of virus infection in vivo. Treatment of human virus-specific CD8 T cells with anti-CEACAM1 antibody similarly enhances their proliferation. We conclude that CEACAM1 is an important regulator of virus-specific CD8 T cell functions in mice and humans and represents a promising therapeutic target for modulating CD8 T cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-018-04832-2Titel-ID: cdi_doaj_primary_oai_doaj_org_article_bede592b38dd44ccaefbb07e0a9f1236
- Format
- –
- Schlagworte
- Adoptive Transfer, Animals, Antigens, CD - metabolism, Bone Marrow Transplantation, Carcinoembryonic antigen, Carcinoembryonic Antigen - genetics, Carcinoembryonic Antigen - metabolism, CD66 antigen, CD8 antigen, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - metabolism, CEACAM1 protein, Cell activation, Cell adhesion, Cell adhesion molecules, Cell Adhesion Molecules - metabolism, Cell proliferation, Chimera, Chronic Disease, Chronic infection, Exhaustion, Female, Humans, Immunological synapses, Immunology, Infections, Kinases, Lck protein, Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism, Lymphocytes, Lymphocytes T, Lymphocytic Choriomeningitis - immunology, Lymphocytic Choriomeningitis - virology, Lymphocytic choriomeningitis virus - immunology, Lymphocytic choriomeningitis virus - pathogenicity, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular chains, Protein kinase, Proteins, T cell receptors, T-cell receptor, Therapeutic applications, Viral infections, Viruses