Details

Autor(en) / Beteiligte

• Noz, Marlies P
• Bekkering, Siroon
• Groh, Laszlo
• Nielen, Tim Mj
• Lamfers, Evert Jp
• Schlitzer, Andreas
• El Messaoudi, Saloua
• van Royen, Niels
• Huys, Erik Hjpg
• Preijers, Frank Wmb
• Smeets, Esther Mm
• Aarntzen, Erik Hjg
• Zhang, Bowen
• Li, Yang
• Bremmers, Manita Ej
• van der Velden, Walter Jfm
• Dolstra, Harry
• Joosten, Leo Ab
• Gomes, Marc E
• Netea, Mihai G
• Riksen, Niels P

Titel

Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

Ist Teil von

• eLife, 2020-11, Vol.9

Ort / Verlag

England: eLife Science Publications, Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived macrophages are the most abundant immune cells in atherosclerotic plaques. In patients with atherosclerotic CVD, leukocytes have a hyperinflammatory phenotype. We hypothesize that immune cell reprogramming in these patients occurs at the level of myeloid progenitors. We included 13 patients with coronary artery disease due to severe atherosclerosis and 13 subjects without atherosclerosis in an exploratory study. Cytokine production capacity after stimulation of peripheral blood mononuclear cells (MNCs) and bone marrow MNCs was higher in patients with atherosclerosis. In BM-MNCs this was associated with increased glycolysis and oxidative phosphorylation. The BM composition was skewed towards myelopoiesis and transcriptome analysis of HSC/GMP cell populations revealed enrichment of neutrophil- and monocyte-related pathways. These results show that in patients with atherosclerosis, activation of innate immune cells occurs at the level of myeloid progenitors, which adds exciting opportunities for novel treatment strategies.