Details

Autor(en) / Beteiligte

• Chen, Yi-Hao
• Chang, Jian-Bo
• Wei, Jun-Ji
• Lyu, Wei
• Yu, Shuang-Ni
• Ma, Bai-Tao
• Wu, Hao
• Zhang, Xiao
• Lian, Wei
• Ma, Wen-Bin
• Wang, Ting-Ting
• Li, Tai-Sheng
• Wang, Ren-Zhi

Titel

Three acquired immunodeficiency syndrome patients with central nervous system infection: diagnostic approach and outcome of treatment

Ist Teil von

• Chinese medical journal, 2019-11, Vol.132 (22), p.2754-2756

Ort / Verlag

China: Lippincott Williams & Wilkins Ovid Technologies

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The patients with acquired immunodeficiency syndrome (AIDS) are prone to opportunistic infections due to immune deficiencies. Because the AIDS virus is neuropathic, 10% of AIDS patients first manifested central nervous system (CNS) symptoms. Total 442 cases were admitted to Chinese Academy of Medical Sciences Peking Union Medical College Hospital with a clear diagnosis of AIDS from 1985 to 2017, and there were three cases diagnosed as intracranial infection confirmed by cerebrospinal fluid (CSF) analysis and brain biopsy. Since routine antiretroviral therapy and empirical treatment did not improve the patient's outcome of disease, we performed the brain biopsy to obtain a specific diagnosis. For simultaneous comorbidities of CNS infection, it is often limited in the improvement of neurological deficit symptoms even if the patient received adequate antiviral and anti-infective therapy. [...]the active intervention including multidisciplinary cooperation and multiple diagnostic techniques, such as biopsy, may have implications to improve the outcomes of AIDS patients complicated with CNS infection.