Details

Autor(en) / Beteiligte

• Ivanisevic, Tonci
• Steklov, Mikhail
• Lechat, Benoit
• Cawthorne, Christopher
• Gsell, Willy
• Velde, Greetje Vande
• Deroose, Christophe
• Van Laere, Koen
• Himmelreich, Uwe
• Sewduth, Raj N
• Sablina, Anna A

Titel

Targeted STAT1 therapy for LZTR1-driven peripheral nerve sheath tumor

Ist Teil von

• Cancer communications (London, England), 2023-12, Vol.43 (12), p.1386-1390

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [...]those who undergo surgery may experience neurological deficits. [...]the management of schwannomas can be problematic due to their unpredictable growth. [...]there is a pressing need for nonsurgical treatments to manage both tumor growth and pain control. [...]our model partially recapitulates schwannoma development, which also appears sporadically and displays unpredictable clinical behavior in patients. [...]we observed an activation of extracellular signal-regulated kinases 1/2 (ERK1/2) upon LZTR1 depletion in NF2-mutated schwannoma cell line HEI-193 (Supplementary Figure S2A). [...]immunohistochemical analysis of vestibulocochlear nerves isolated from the triple knockout mice also revealed increased cell proliferation and higher levels of macrophage infiltration as detected by Ki67 and F4/80 immunostainings, respectively (Figure 1A, Supplementary Figure S2B).