Details

Autor(en) / Beteiligte

• Soderborg, Taylor K
• Clark, Sarah E
• Mulligan, Christopher E
• Janssen, Rachel C
• Babcock, Lyndsey
• Ir, Diana
• Young, Bridget
• Krebs, Nancy
• Lemas, Dominick J
• Johnson, Linda K
• Weir, Tiffany
• Lenz, Laurel L
• Frank, Daniel N
• Hernandez, Teri L
• Kuhn, Kristine A
• D'Alessandro, Angelo
• Barbour, Linda A
• El Kasmi, Karim C
• Friedman, Jacob E

Titel

The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

Ist Teil von

• Nature communications, 2018-10, Vol.9 (1), p.4462-12, Article 4462

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant gut by microbes plays a critical role in establishing immunity and metabolic function. Here, we compare germ-free mice colonized with stool microbes (MB) from 2-week-old infants born to obese (Inf-ObMB) or normal-weight (Inf-NWMB) mothers. Inf-ObMB-colonized mice demonstrate increased hepatic gene expression for endoplasmic reticulum stress and innate immunity together with histological signs of periportal inflammation, a histological pattern more commonly reported in pediatric cases of NAFLD. Inf-ObMB mice show increased intestinal permeability, reduced macrophage phagocytosis, and dampened cytokine production suggestive of impaired macrophage function. Furthermore, exposure to a Western-style diet in Inf-ObMB mice promotes excess weight gain and accelerates NAFLD. Overall, these results provide functional evidence supporting a causative role of maternal obesity-associated infant dysbiosis in childhood obesity and NAFLD.