Details

Autor(en) / Beteiligte

• Poon, Carole L C
• Brumby, Anthony M
• Richardson, Helena E

Titel

Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue

Ist Teil von

• International journal of molecular sciences, 2018-05, Vol.19 (6), p.1585

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2018

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The oncogene (Rat Sarcoma oncogene, a small GTPase) is a key driver of human cancer, however alone it is insufficient to produce malignancy, due to the induction of cell cycle arrest or senescence. In a genetic screen for genes that cooperate with oncogenic (bearing the mutation, or ), we identified the (Sarcoma virus oncogene) family non-receptor tyrosine protein kinase genes, and , as promoting increased hyperplasia in a whole epithelial tissue context in the eye. Moreover, overexpression of cooperated with in epithelial cell clones to drive neoplastic tumourigenesis. We found that overexpression alone activated the Jun N-terminal Kinase (JNK) signalling pathway to promote actin cytoskeletal and cell polarity defects and drive apoptosis, whereas, in cooperation with , JNK led to a loss of differentiation and an invasive phenotype. cooperative tumourigenesis was dependent on JNK as well as Phosphoinositide 3-Kinase (PI3K) signalling, suggesting that targeting these pathways might provide novel therapeutic opportunities in cancers dependent on Src and Ras signalling.