Details

Autor(en) / Beteiligte

• Senner, Fanny
• Schneider-Axmann, Thomas
• Kaurani, Lalit
• Zimmermann, Jörg
• Wiltfang, Jens
• von Hagen, Martin
• Vogl, Thomas
• Spitzer, Carsten
• Senner, Simon
• Schulte, Eva C.
• Schmauß, Max
• Schaupp, Sabrina K.
• Reimer, Jens
• Reich-Erkelenz, Daniela
• Papiol, Sergi
• Kohshour, Mojtaba Oraki
• Lang, Fabian U.
• Konrad, Carsten
• Kirchner, Sophie-Kathrin
• Kalman, Janos L.
• Juckel, Georg
• Heilbronner, Maria
• Heilbronner, Urs
• Figge, Christian
• Eyl, Ruth E.
• Dietrich, Detlef
• Budde, Monika
• Angelescu, Ion-George
• Adorjan, Kristina
• Schmitt, Andrea
• Fischer, Andre
• Falkai, Peter
• Schulze, Thomas G.

Titel

Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls

Ist Teil von

• Schizophrenia research. Cognition, 2023-06, Vol.32, p.100280-100280, Article 100280

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• As core symptoms of schizophrenia, cognitive deficits contribute substantially to poor outcomes. Early life stress (ELS) can negatively affect cognition in patients with schizophrenia and healthy controls, but the exact nature of the mediating factors is unclear. Therefore, we investigated how ELS, education, and symptom burden are related to cognitive performance. The sample comprised 215 patients with schizophrenia (age, 42.9 ± 12.0 years; 66.0 % male) and 197 healthy controls (age, 38.5 ± 16.4 years; 39.3 % male) from the PsyCourse Study. ELS was assessed with the Childhood Trauma Screener (CTS). We used analyses of covariance and correlation analyses to investigate the association of total ELS load and ELS subtypes with cognitive performance. ELS was reported by 52.1 % of patients and 24.9 % of controls. Independent of ELS, cognitive performance on neuropsychological tests was lower in patients than controls (p < 0.001). ELS load was more closely associated with neurocognitive deficits (cognitive composite score) in controls (r = −0.305, p < 0.001) than in patients (r = −0.163, p = 0.033). Moreover, the higher the ELS load, the more cognitive deficits were found in controls (r = −0.200, p = 0.006), while in patients, this correlation was not significant after adjusting for PANSS. ELS load was more strongly associated with cognitive deficits in healthy controls than in patients. In patients, disease-related positive and negative symptoms may mask the effects of ELS-related cognitive deficits. ELS subtypes were associated with impairments in various cognitive domains. Cognitive deficits appear to be mediated through higher symptom burden and lower educational level. •Early life stress is often reported by patients with schizophrenia (52.1%) and healthy controls (24.9%).•Early life stress is more strongly associated with neurocognitive deficits in controls than in patients with schizophrenia.•The higher the early life stress load, the more symptoms and cognitive deficits are found.•Disease-related symptoms may mask the effects of early life stress-related cognitive deficits in patients with schizophrenia.•Cognitive deficits appear to be mediated through higher symptom burden and lower educational level.