Details

Autor(en) / Beteiligte

• Craig, Daniel J.
• Ambrose, Stephanie
• Stanbery, Laura
• Walter, Adam
• Nemunaitis, John

Titel

Systemic benefit of radiation therapy via abscopal effect

Ist Teil von

• Frontiers in oncology, 2022-10, Vol.12, p.987142-987142

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Evidence of a systemic response related to localized radiation therapy (RT) in cancer management is rare. However, enhancing the immune response via immunotherapy followed by localized RT has shown evidence of tumor shrinkage to non-irradiated metastatic disease thereby inducing an “abscopal effect.” Combined induction of the cGAS-STING pathway and activation of IFN-gamma signaling cascade related to RT within an activated immune environment promotes neoantigen presentation and expansion of cytotoxic effector cells enabling enhancement of systemic immune response. A proposed mechanism, case examples, and clinical trial evidence of “abscopal effect” benefit are reviewed. Results support strategic therapeutic testing to enhance “abscopal effect.”