Details

Autor(en) / Beteiligte

• Gani, C.
• Bonomo, P.
• Zwirner, K.
• Schroeder, C.
• Menegakis, A.
• Rödel, C.
• Zips, D.

Titel

Organ preservation in rectal cancer – Challenges and future strategies

Ist Teil von

• Clinical and translational radiation oncology, 2017-04, Vol.3 (C), p.9-15

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Neoadjuvant radiochemotherapy with subsequent total mesorectal excision is the standard of care for locally advanced rectal cancer. While this multimodal strategy has decreased local recurrences rates below 5%, long-term morbidities are considerable in terms of urinary, sexual or bowel functioning. At the same time approximately 10–20% of patients have no evidence of residual tumour in their surgical specimen. Pioneering studies from Brazil have suggested that surgery can safely be omitted in carefully selected patients with a clinical complete response after radiochemotherapy. Although confirmatory studies showed similar results, challenges in terms of optimizing radiochemotherapy for organ-preservation, appropriate selection of patients for non-operative management and the safety of this approach remain. The present review will summarize the current data on organ-preservation in rectal cancer and discuss the challenges that need to be addressed in future trials.