Details

Autor(en) / Beteiligte

• Albrecht, Letusa
• Lopes, Stefanie C P
• da Silva, Ana Beatriz Iung Enembreck
• Barbosa, Vanessa
• Almeida, Rodrigo P
• Siqueira, André M
• Leite, Juliana Almeida
• Bittencourt, Najara C
• Dos Santos, Hellen Geremias
• Bourgard, Catarina
• Garcia, Luiz Fernando Cardoso
• Kayano, Ana Carolina A V
• Soares, Irene S
• Russell, Bruce
• Rénia, Laurent
• Lacerda, Marcus V G
• Costa, Fabio T M

Titel

Rosettes integrity protects Plasmodium vivax of being phagocytized

Ist Teil von

• Scientific reports, 2020-10, Vol.10 (1), p.16706-16706, Article 16706

Ort / Verlag

England: Nature Publishing Group UK

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Plasmodium vivax is the most prevalent cause of malaria outside of Africa. P. vivax biology and pathogenesis are still poorly understood. The role of one highly occurring phenotype in particular where infected reticulocytes cytoadhere to noninfected normocytes, forming rosettes, remains unknown. Here, using a range of ex vivo approaches, we showed that P. vivax rosetting rates were enhanced by plasma of infected patients and that total immunoglobulin M levels correlated with rosetting frequency. Moreover, rosetting rates were also correlated with parasitemia, IL-6 and IL-10 levels in infected patients. Transcriptomic analysis of peripheral leukocytes from P. vivax-infected patients with low or moderated rosetting rates identified differentially expressed genes related to human host phagocytosis pathway. In addition, phagocytosis assay showed that rosetting parasites were less phagocyted. Collectively, these results showed that rosette formation plays a role in host immune response by hampering leukocyte phagocytosis. Thus, these findings suggest that rosetting could be an effective P. vivax immune evasion strategy.