Details

Autor(en) / Beteiligte

• Salehi, Bahare
• Quispe, Cristina
• Chamkhi, Imane
• El Omari, Nasreddine
• Balahbib, Abdelaali
• Sharifi-Rad, Javad
• Bouyahya, Abdelhakim
• Akram, Muhammad
• Iqbal, Mehwish
• Docea, Anca Oana
• Caruntu, Constantin
• Leyva-Gómez, Gerardo
• Dey, Abhijit
• Martorell, Miquel
• Calina, Daniela
• López, Víctor
• Les, Francisco

Titel

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Ist Teil von

• Frontiers in pharmacology, 2021-01, Vol.11, p.592654

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules.