Details

Autor(en) / Beteiligte

• Sun, Lina
• Paschall, Amy V
• Middleton, Dustin R
• Ishihara, Mayumi
• Ozdilek, Ahmet
• Wantuch, Paeton L
• Aceil, Javid
• Duke, Jeremy A
• LaBranche, Celia C
• Tiemeyer, Michael
• Avci, Fikri Y

Titel

Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

Ist Teil von

• Nature communications, 2020-05, Vol.11 (1), p.2550-2550, Article 2550

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The inherent molecular complexity of human pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation of non-conventional MHC ligands derived from disease-causing agents, such as HIV-1 envelope (Env) glycoprotein. Here, we report that a CD4 T cell repertoire recognizes a glycopeptide epitope on gp120 presented by MHCII pathway. This glycopeptide is strongly immunogenic in eliciting glycan-dependent cellular and humoral immune responses. The glycopeptide specific CD4 T cells display a prominent feature of Th2 and Th17 differentiation and exert high efficacy and potency to help Env trimer humoral immune responses. Glycopeptide-induced CD4 T cell response prior to Env trimer immunization elicits neutralizing antibody development and production of antibodies facilitating uptake of immunogens by antigen-presenting cells. Our identification of gp120 glycopeptide-induced, T cell-specific immune responses offers a foundation for developing future knowledge-based vaccines that elicit strong and long-lasting protective immune responses against HIV-1 infection.